kaqun water canada

Kaqun Studies

Following are all studies on Kaqun water to date.

2012 - Therapeutic effect by a mistletoe extract, Iscador and oxygen enriched water (Kaqun) on the development of experimental tumor (A2780, KB-3-1) growth in a scid mice model

studies 3Kaqun is a special water with high oxygen content, suitable for use in the form of drinking water or bathing. As a result of the KAQUN technology oxygen is present in a stable form with a concentration of 18-25 mg/l, which is manifold of the oxygen content of normal drinking water. Killing of cancer cells by macrophages in a non-ADCC manner via apoptosis is induced by reactive oxygen species (ROS). (Hicks AM, Willingham MC, Du W, Pang CS, Old LJ, Cui Z: Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice. Cancer Immun. 2006 Oct 31;6:11). It was also observed, that target cell antioxidant mechanisms play an important role in the outcome of the cytotoxic response of human polymorphonuclear leukocytes (PMN) against red blood cells (RBC) and K562 tumor cells (van Kessel KP, van Strijp JA, van Kats-Renaud HJ, Miltenburg LA, Fluit AC, Verhoef J.: Uncoupling of oxidative and non-oxidative mechanisms in human granulocyte-mediated cytotoxicity: use of cytoplasts and cells from chronic granulomatous disease patient. J Leukoc Biol. 1990 Oct;48(4):359-66). Kaqun water has a significant influence on grow of tumor cells in vitro, although there are great differences between its effect on different cell lines. It has no influence on Hep G2 (human hepatocellular carcinoma) cells (02-ctox-10, OKBI-KBKF Budapest, 2010.12.20), while it significantly decreases the growth of LLT-HH (highly metastatic variant of Lewis lung carcinoma) and H59 (Lewis Lung Carcinoma Variant) cell lines in a dose dependent manner (). Furthermore human experiences suggest a benefit effect of kanqun water on several human tumors (including ovarian carcinoma) (xx)

UNIVERSITAS DEBRECENIENSIS

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2012 - Report about effects of Kaqun water on the speed of cognitive functions - Permit Number: IV-R-015-14-4/2012

studies 1Our research project: The effects of Kaqun water on the speed of cognitive functions” was conducted on randomly selected healthy elderly individuals who fit the age group. The average age of the groups was around 65 years. We made 4 groups, 1.5l; 1l; 0.5l daily consumption of Kaqun water as well as the control group whose members drank 1l tap water. During the measurements the people who made the measurements and who assessed the results did not know who was in which group, it was only made known to them after the data have been processed (double blind). The connection between the dose and the therapeutic effect has also been examined.

We examined: plethysmogram, the spread of the pulse relaxed and under load with tools of HRV analysis; blood pressure (systolic and diastolic), oxygen saturation, SRT (reaction time) and CRT (cognitive reflex time).

The results of the measurements and the significance of the changes were assessed by RopStat software.

SOUTH BORSOD HEALTH CARE SOCIAL CLUSTER

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2011 - Study for the KAQUN’s effect for antioxydant capacity (TUKEB No.: 550/2011)

studies 2Aim of the study
Our aim was to study the effect of a regimen of bathing and drinking Kaqun water on the antioxidant capacity of healthy volunteers, to establish whether the treatment changes the antioxidant parameter compared to the value before treatment, and whether the gender of the subject affects the measured parameters. The studied parameters were analysed at individual and group level. The total antioxidant capacity of serum and erythrocyte lysate obtained from whole blood was evaluated, compared to the 0 point, initial values.

NATIONAL INSTITUTE OF CHEMICAL SAFETY -  DEPARTMENT OF MOLECULAR AND CELL BIOLOGY

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2010 - Citotoxicity examination of Kaqun water in HepG2 cells /NICS/

studies 2PRINCIPAL INVESTIGATOR’S DECLARATION
I the undersigned hereby declare that the toxicity examination titled Citotoxicity examination of Kaqun water in HepG2 cells (with examination number: 02-CTOX-10) was carried out in compliance with the regulations of OECD Principles of Good Laboratory Practice (ENV/MC/CHEM(98)17) at the Molecular and Cell Biological Department of the Department of Research for Chemical Safety of the National Institute of Chemical Safety (OKBI).

The examination was carried out based on the decrees titled Biological evaluation of medical devices Part 5: Tests for citotoxicity: in vitro methods (ISO 10993-5: 1992), MSZ EN 30993-5:1998; Biological evaluation of medical devices Part 12: Sample preparation and reference materials (ISO 10993-12: 2007), MSZ EN 10993-12:2008.

The examination was carried out according to Standard Operations Regulations of OKBIKBKF-MSBO.
The Closing Report is based on correct examination data and the obtained results are in compliance with the content of the Closing Report.

NATIONAL INSTITUTE OF CHEMICAL SAFETY -  DEPARTMENT OF MOLECULAR AND CELL BIOLOGY

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2010 - Report on the examination of KAQUN oxygen-rich water's role in reactive oxygen species generation in in vitro system /HAS/

studies 2The principle of the method
Horse radish peroxidase produces reactive oxygen species from peroxide. This converts benzidine into a colourful product with kinoid structure. The change of colour concentration may be photometrically measured at 620 nm. Thus the system – being a highly sensitive procedure - is suitable for detecting reactive oxygen species. By the use of this method it can be assessed whether oxygen-rich water increases the quantity of reactive oxygen species in the system or not. Peroxidase first reduces molecular oxygen solved in the oxygen-rich water to peroxide, then thus produces a greater quantity of reactive oxygen species from the increased peroxide in the system.

This method may also be used for measuring antioxidant capacity. The presence of an antioxidant, e.g. ascorbic acid, poliphenol, or uric acid inhibits the formation of the colour.

NATIONAL INSTITUTE OF CHEMICAL SAFETY -  DEPARTMENT OF MOLECULAR AND CELL BIOLOGY

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2009 - The effect of KAQUN water on the immune parameters of healthy volunteers (TUKEB No.: 42/2009)

studies 2Summary

  1. No biologically significant changes were observed in the qualitative and quantitative blood count either at group level or individual level during the 21 days of Kaqun treatment.
  2. The percentage of NK-cells showed a statistically significant increase, and the individual changes (increase) relative to the 0 point were bigger, which may have a functional impact, namely that more NK cells are available to kill virus infected and cancerous cells.
  3. A non-specific activation of T lymphocytes (indicated by the increase in the expression of the CD25 cell surface antigen) could be detected, presumably caused by the Kaqun treatment, indicating the increased activity of the cellular immune response.
  4. Characteristically the value of several parameters changed significantly by the second week of treatment and during the third week the value of the parameter remained at the same level, or the change levelled to its original value (percent of neurophils, monocytes, activated (CD25+) T cells, activated (CD25+) helper T cells and CD71+ B cells). This suggests that two weeks treatment is the most effective for the change in immune parameters and after that the reaction of the body to the treatment decreases, that is, the effect cannot be boosted.
  5. The increase of the production of reactive oxygen intermediates both at group level and at the level of the individuals results in the intensification of the killing potential of neurophil granulocytes.

NATIONAL INSTITUTE OF CHEMICAL SAFETY - CITOGENETIC AND IMMUNOLOGIC DIVISION

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2007 - The Psycho-physiological effects of the high OXYGEN content „KAQUN WATER” drinking cure and bath

studies 5Introduction
The results of earlier examinations suggested that the consumption of the high oxygen content kaqun water results in an increase in the oxygen saturation. On behalf of the Centrion Hungária Ltd. we have examined the change in the other physiological parameters we agreed on.

The aim of this study is to examine objectively the oxygen saturation, the reaction time, the exertion of forces, the blood pressure, the data can be derived from the ECG, the stress index and the standing stability during the continuous consumption of the high oxygen content Kaqun water and before and after a simultaneous Kaqun bath.

We can conclude that in the empirical measurements conducted we experienced favourable effects. The registered, mostly encouraging results can be the result of several factors. Among them there is the favourable effect of the high oxygen content Kaqun water by the increase in the oxygen saturation.

SEMMELWEIS UNIVERSITY

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2004 - Examination of the effects of high oxygen content water on tumor cells

studies 4During our experiments we examined the encumbering effects on tumour cells of oxygenated water, that is KQN water, with mice tumour lines.

Growing of cell lines
We used 2 cell lines (H59, LLT- ??) in our experiments. The H59 is less malignant, while the LLT-?? is a Lewis Lung tumour line with a strong metastatic ability. There is a separate documentation on its deposition. We grew the tumour cells in RP?I-1640 nutritive solution, we added 5-10% of FCS (GIBCO) 0.01 ? ????S and 2?10—3 ? of glutamine and we grew the tumour cells for 4-10 days in it for the purpose of the experiments.

HUNGARIAN ACADEMY OF SCIENCES - INSTITUTE OF ISOTOPES

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Ongoing Studies

2013 - The effects of KAQUN-water on patients undergoing oncology treatment – a randomized study

studies 6The effects of KAQUN-water on patients undergoing oncology treatment – a randomized study
Dr. Gabriella Liszkay - National Institute of Oncology

Aim: to study the effects of Kaqun-water on patients undergoing oncological treatment.
Primary endpoints: radiation-induced dermatitis, drug-induced dermatitis, fitness and state of mind, studying changes in exulceration.
Secondary endpoints: changes in cutaneous manifestations of melanoma, tumor response in complex oncotherapy of stage IV melanoma.
Estimated end of the study: Q1 2014

NATIONAL INSTITUTE OF ONCOLOGY - Dr. Gabriella Liszkay

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studies 2

Studies Under Authorization

2013 - Study for the KAQUN water’s effect for humoral immune reaction

NATIONAL INSTITUTE OF CHEMICAL SAFETY -  DEPARTMENT OF MOLECULAR AND CELL BIOLOGY

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studies 4Non-TUKEB

2013 - Functioning of the KAQUN water

HUNGARIAN ACADEMY OF SCIENCES - INSTITUTE OF ISOTOPES

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(TUKEB = Scientific and Research Ethics Committee)

studies 32013 - Mouse trials for  ovarium carcinoma, cervix carcinoma

UNIVERSITAS DEBRECENIENSIS

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